About Enhancer
| Enhancer ID: | E_01446 |
| Species: | Homo sapiens |
| Position : | chr5:129345600-129346600   |
| Year: | 2025 |
| Title: | Enhancer-Associated LncRNA-ITGA2 Promotes Vascular Remodeling Through ITGA2 |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40321134 |
| MONDO: | |
| Tissue: | Artery |
| Tissue Ontology ID: | UBERON:0001637 |
| Cell Source: | Primary human VSMCs |
| CVCL ID: | |
| Cell Type: | vascular smooth muscle cell |
| Cell Ontology ID: | CL:0000192 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, CRISPRi, RT-RT-qPCR, Western blot, EMSA |
About Target Gene
| Target gene : | ITGA2 |
About TF
| TF name : | SRF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SRF | Coregulation of Androgen receptor activity | pid | 61 |
| SRF | ErbB1 downstream signaling | pid | 105 |
| SRF | Interleukin signaling pathway | panther | 86 |
| SRF | p38 MAPK pathway | panther | 31 |
| SRF | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| SRF | PDGF signaling pathway | panther | 113 |
| SRF | PDGFR-alpha signaling pathway | pid | 22 |
| SRF | PDGFR-beta signaling pathway | pid | 125 |
| SRF | Ras Pathway | panther | 69 |
| SRF | RHO GTPases Activate Formins | reactome | 114 |
| SRF | RhoA signaling pathway | pid | 46 |
| SRF | Signaling events mediated by HDAC Class II | pid | 58 |
| SRF | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| SRF | MAPK signaling pathway | kegg | 264 |
| SRF | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| SRF | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| SRF | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| SRF | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer