About Enhancer
| Enhancer ID: | E_01447 |
| Species: | Homo sapiens |
| Position : | chr6:135581000-135583000   |
| Year: | 2024 |
| Title: | Integrated enhancer regulatory network by enhancer-promoter looping in gastric cancer |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | gastric adenocarcinoma |
| PMID: | 38720882 |
| MONDO: | MONDO:0005050 |
| Tissue: | Stomach |
| Tissue Ontology ID: | UBERON:0000945 |
| Cell Source: | MKN45 |
| CVCL ID: | CVCL_0434 |
| Cell Type: | gastric adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay |
| High Throughput Method: | HiChIP, ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPR Knockout/CRISPRi, RT-RT-qPCR, ChIP-RT-qPCR |
About Target Gene
| Target gene : | MYB |
About TF
| TF name : | TCF7 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF7 | Angiogenesis | panther | 141 |
| TCF7 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| TCF7 | Ca2+ pathway | reactome | 62 |
| TCF7 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| TCF7 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF7 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| TCF7 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF7 | Repression of WNT target genes | reactome | 14 |
| TCF7 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| TCF7 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7 | Wnt signaling pathway | kegg | 135 |
| TCF7 | Adherens junction | kegg | 70 |
| TCF7 | Melanogenesis | kegg | 100 |
| TCF7 | Pathways in cancer | kegg | 321 |
| TCF7 | Colorectal cancer | kegg | 63 |
| TCF7 | Endometrial cancer | kegg | 52 |
| TCF7 | Prostate cancer | kegg | 85 |
| TCF7 | Acute myeloid leukemia | kegg | 53 |
| TCF7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
| TCF7 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer