About Enhancer
| Enhancer ID: | E_01452 |
| Species: | Homo sapiens |
| Position : | chr16:11075000-11075280   |
| Year: | 2025 |
| Title: | Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus Susceptibility |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Burkitt lymphoma |
| PMID: | 39796169 |
| MONDO: | MONDO:0002483 |
| Tissue: | Lymph node |
| Tissue Ontology ID: | UBERON:0000029 |
| Cell Source: | Namalwa (B-lymphocyte) |
| CVCL ID: | CVCL_0128 |
| Cell Type: | Burkitt lymphoma cell |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, Luciferase Reporter Assay |
| Low Throughput Method: | CRISPR Knockout, siRNA Knockdown, RT-RT-qPCR, CRISPRa (dCas9-VPR, dCas9-TET1), CRISPRi (dCas9-DNMT3A, dCas9-MeCP2), Western blot |
About Target Gene
| Target gene : | CLEC16A |
About TF
| TF name : | CTCF; STAT3; GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01770 | chr16:11075050-11075232 | Heart | iPSC-derived cardiac fibroblast | -- |
Expression of Target Genes for the Enhancer