About Enhancer
| Enhancer ID: | E_01457 |
| Species: | Homo sapiens |
| Position : | chr7:108960000-108961000   |
| Year: | 2024 |
| Title: | TWEAK/Fn14 signalling driven superenhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancer |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 38965263 |
| MONDO: | MONDO:0006120 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MDA-MB-231 |
| CVCL ID: | CVCL_0062 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq, HiChIP |
| Low Throughput Method: | CRISPR Knockout, ChIP-RT-qPCR, qRT-PCR, Western blot |
About Target Gene
| Target gene : | NAMPT |
About TF
| TF name : | MAFG |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MAFG | AP-1 transcription factor network | pid | 71 |
| MAFG | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer