About Enhancer
| Enhancer ID: | E_01469 |
| Species: | Homo sapiens |
| Position : | chr1:150509075-150512075   |
| Year: | 2023 |
| Title: | ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic Leukemia |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 36350827 |
| MONDO: | |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Alveolar type I cells |
| CVCL ID: | |
| Cell Type: | alveolar epithelial type I cell |
| Cell Ontology ID: | CL:0002062 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPRi, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | TNS1 |
About TF
| TF name : | ERG |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ERG | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ERG | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ERG | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ERG | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ERG | PDGF signaling pathway | panther | 113 |
| ERG | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01468 | chr1:150509075-150512075 | Blood | umbilical cord blood hematopoietic cell | acute myeloid leukemia |
| E_01470 | chr1:150509075-150512075 | Lung | alveolar epithelial type II cell | -- |
| E_01471 | chr1:150509075-150512075 | Blood | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer