About Enhancer
| Enhancer ID: | E_01509 |
| Species: | Mus musculus |
| Position : | chr11:10996600-10999794   |
| Year: | 2018 |
| Title: | Sex reversal following deletion of a single distal enhancer of Sox9. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | sex reversal |
| PMID: | 29903884 |
| MONDO: | MONDO:0008637 |
| Tissue: | testis |
| Tissue Ontology ID: | UBERON:0000473 |
| Cell Source: | Sertoli cell precursors |
| Cell Type: | Sertoli cell precursor |
| Experiment Type: | Developmental biology assay, Functional genomics assay, Epigenomic profiling assay, Genome editing assay, Transcriptional regulation assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq; DNase-seq; ATAC-seq |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; RT-RT-qPCR; ChIP-RT-qPCR; Immunofluorescence; Genotyping PCR; Sanger Sequencing |
About Target Gene
| Target gene : | Sox9 |
About TF
| TF name : | Sry |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sry | AndrogenReceptor | netpath | 167 |
| Sry | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sry | Regulation of Androgen receptor activity | pid | 54 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01507 | chr11:10996600-10999794 | testis | Sertoli cell precursor | sex reversal |
| E_01508 | chr11:10996600-10999794 | testis | Sertoli cell precursor | sex reversal |
| E_01520 | chr11:10997900-10999300 | testis | Sertoli cell precursor | sex reversal |
| E_01521 | chr11:10997900-10999300 | testis | Sertoli cell precursor | sex reversal |
| E_01522 | chr11:10997900-10999300 | testis | Sertoli cell precursor | sex reversal |
Expression of Target Genes for the Enhancer