About Enhancer
| Enhancer ID: | E_01512 |
| Species: | Mus musculus |
| Position : | chr11:112078592-112079149   |
| Year: | 2018 |
| Title: | Sex reversal following deletion of a single distal enhancer of Sox9. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 29903884 |
| Tissue: | testis |
| Tissue Ontology ID: | UBERON:0000473 |
| Cell Source: | embryonic gonad |
| Cell Type: | Sertoli cell lineage |
| Experiment Type: | 557-bp Sox9 Enh13 (original paper coordinate); essential endogenous sex-determining enhancer |
| High Throughput Method: | ATAC-seq/DNase-seq; comparative epigenomics |
| Low Throughput Method: | Transgenic enhancer reporter assay; CRISPR/Cas9 Enh13 deletion mouse; RT-qPCR |
About Target Gene
| Target gene : | Sox9 |
About TF
| TF name : | Sry |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sry | AndrogenReceptor | netpath | 167 |
| Sry | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sry | Regulation of Androgen receptor activity | pid | 54 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
No overlapping enhancers found in mm9 at this locus.
Expression of Target Genes for the Enhancer