About Enhancer
| Enhancer ID: | E_01514 |
| Species: | Homo sapiens |
| Position : | chr10:17275000-17276500   |
| Year: | 2021 |
| Title: | TNF-??-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 35122059 |
| MONDO: | MONDO:0005147 |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | primary PDAC cells |
| CVCL ID: | |
| Cell Type: | pancreatic ductal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, cJUN Overexpression Assay, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | VIM |
About TF
| TF name : | CJUN |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01513 | chr10:17275000-17276500 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer