About Enhancer
| Enhancer ID: | E_01517 |
| Species: | Homo sapiens |
| Position : | chr6:45296454-45506241   |
| Year: | 2025 |
| Title: | ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 40781158 |
| MONDO: | MONDO:0005147 |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | PANC-1 |
| CVCL ID: | CVCL_0480 |
| Cell Type: | pancreatic ductal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, TF binding assay |
| High Throughput Method: | ATAC-seq, CUT&Tag, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, RT-RT-qPCR, Western blot, CCK-8 Assay |
About Target Gene
| Target gene : | RUNX2 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01518 | chr6:45296454-45506241 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
| E_01537 | chr6:45407433-45444666 | Thyroid | thyroid carcinoma cell | thyroid carcinoma |
| E_01538 | chr6:45407433-45444666 | Thyroid | thyroid carcinoma cell | thyroid carcinoma |
Expression of Target Genes for the Enhancer