About Enhancer
| Enhancer ID: | E_01525 |
| Species: | Mus musculus |
| Position : | chr12:8570500-8571000   |
| Year: | 2021 |
| Title: | Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 34260936 |
| Tissue: | cerebral cortex |
| Tissue Ontology ID: | UBERON:0000956 |
| Cell Source: | Primary mouse cortical neurons |
| Cell Type: | cortical neuron |
| Experiment Type: | Activity-induced enhancer assay; Chromatin remodeling/looping assay; In vivo phosphosite knock-in functional assay |
| High Throughput Method: | BRG1/H3K27ac/cohesin ChIP-seq; ATAC-seq; RNA-seq |
| Low Throughput Method: | ChIP-qPCR; 3C; enhancer RNA/gene RT-qPCR; Western blot; SMARCA4 phosphosite knock-in mouse phenotyping |
About Target Gene
| Target gene : | Fos |
About TF
| TF name : | Smarca4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Smarca4 | BMP signaling in Drosophila ( BMP signaling in Drosophila ) | inoh | 7 |
| Smarca4 | BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) | inoh | 7 |
| Smarca4 | BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) | inoh | 7 |
| Smarca4 | BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 34 |
| Smarca4 | Direct p53 effectors | pid | 141 |
| Smarca4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Smarca4 | Glucocorticoid receptor regulatory network | pid | 85 |
| Smarca4 | RANKL | netpath | 84 |
| Smarca4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Smarca4 | Regulation of retinoblastoma protein | pid | 67 |
| Smarca4 | RMTs methylate histone arginines | reactome | 75 |
| Smarca4 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Smarca4 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Smarca4 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Smarca4 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Smarca4 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Smarca4 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Smarca4 | TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 51 |
| Smarca4 | TNFalpha | netpath | 274 |
| Smarca4 | Validated nuclear estrogen receptor beta network | pid | 15 |
| Smarca4 | Wnt signaling pathway | panther | 250 |
| Smarca4 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer