About Enhancer
| Enhancer ID: | E_01526 |
| Species: | Mus musculus |
| Position : | chr16:25574210-25575090   |
| Year: | 2020 |
| Title: | ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 32701507 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | LCD prostate organoids |
| Cell Type: | prostate epithelial cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay |
| High Throughput Method: | ERG ChIP-seq; H3K27ac ChIP-seq; BL-Hi-C |
| Low Throughput Method: | CRISPR/Cas9 enhancer deletion; qRT-PCR |
About Target Gene
| Target gene : | Trp63 |
About TF
| TF name : | Erg |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Erg | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| Erg | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| Erg | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| Erg | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| Erg | PDGF signaling pathway | panther | 113 |
| Erg | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01581 | chr16:25400000-25900000 | prostate gland | mouse prostate epithelial organoid cell | prostate cancer |
Expression of Target Genes for the Enhancer