About Enhancer
| Enhancer ID: | E_01530 |
| Species: | Mus musculus |
| Position : | chr14:57520000-57525000   |
| Year: | 2024 |
| Title: | Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 38341433 |
| Tissue: | skeletal muscle tissue |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast |
| Cell Ontology ID: | CL:0000056 |
| Experiment Type: | Chromatin interaction assay; TF binding assay; Chromatin accessibility assay; Functional perturbation assay |
| High Throughput Method: | Hi-C; ATAC-seq; MyoD CUT&RUN; YY1 CUT&RUN; H3K27ac profiling; RNA-seq; SLAM-seq |
| Low Throughput Method: | CRISPR-Cas9 Matr3 knockout; dTAG47-mediated acute Matr3 degradation; Yy1 knockout; Western blot; Immunofluorescence; C2C12 myogenic differentiation assay |
About Target Gene
| Target gene : | Mphosph8 |
About TF
| TF name : | Myod1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Myod1 | C-MYB transcription factor network | pid | 87 |
| Myod1 | CDO in myogenesis | reactome | 29 |
| Myod1 | ID | netpath | 38 |
| Myod1 | Notch-mediated HES/HEY network | pid | 48 |
| Myod1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Myod1 | Regulation of retinoblastoma protein | pid | 67 |
| Myod1 | Signaling events mediated by HDAC Class III | pid | 41 |
| Myod1 | Hs_ID_signaling_pathway_WP53_67360 | wikipathways | 8 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01531 | chr14:57520000-57525000 | skeletal muscle tissue | myoblast | NA |
Expression of Target Genes for the Enhancer