About Enhancer
| Enhancer ID: | E_01531 |
| Species: | Mus musculus |
| Position : | chr14:57520000-57525000   |
| Year: | 2024 |
| Title: | Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 38341433 |
| Tissue: | skeletal muscle tissue |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast |
| Cell Ontology ID: | CL:0000056 |
| Experiment Type: | Chromatin interaction assay; TF binding assay; Chromatin accessibility assay; Functional perturbation assay |
| High Throughput Method: | Hi-C; ATAC-seq; CUT&RUN; ChIP-seq; RNA-seq; SLAM-seq |
| Low Throughput Method: | CRISPR-Cas9 Matr3 knockout; dTAG47-mediated acute Matr3 degradation; Yy1 knockout; Western blot; Immunofluorescence; C2C12 myogenic differentiation assay |
About Target Gene
| Target gene : | Mphosph8 |
About TF
| TF name : | Yy1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Yy1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Yy1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| Yy1 | E2F transcription factor network | pid | 77 |
| Yy1 | mTOR signaling pathway | pid | 66 |
| Yy1 | Notch-mediated HES/HEY network | pid | 48 |
| Yy1 | Notch | netpath | 76 |
| Yy1 | Notch signaling pathway | pid | 58 |
| Yy1 | p53 pathway | pid | 59 |
| Yy1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01530 | chr14:57520000-57525000 | skeletal muscle tissue | myoblast | NA |
Expression of Target Genes for the Enhancer