About Enhancer
| Enhancer ID: | E_01541 |
| Species: | Homo sapiens |
| Position : | chr1:158000000-158500000   |
| Year: | 2020 |
| Title: | Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 32933554 |
| MONDO: | MONDO:0004947 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary T-ALL patient |
| CVCL ID: | |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, Hi-C, ATAC-seq, RNA-seq |
| Low Throughput Method: | RT-RT-qPCR, Western blot |
About TF
| TF name : | CTCF; NOTCH1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01527 | chr1:158000000-158500000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01539 | chr1:158000000-158500000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01540 | chr1:158000000-158500000 | Lymphoid tissue | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01542 | chr1:158000000-158500000 | Blood | CD4-positive T cell | -- |
Expression of Target Genes for the Enhancer