About Enhancer
| Enhancer ID: | E_01577 |
| Species: | Homo sapiens |
| Position : | chr17:40252000-40253000   |
| Year: | 2025 |
| Title: | Bclaf1 mediates super-enhancer-driven activation of POLR2A to enhance chromatin accessibility in nitrosamine-induced esophageal carcinogenesis |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | esophageal squamous cell carcinoma |
| PMID: | 40220379 |
| MONDO: | MONDO:0005082 |
| Tissue: | Esophagus |
| Tissue Ontology ID: | UBERON:0001043 |
| Cell Source: | MNNG-M cells |
| CVCL ID: | CVCL_1360 |
| Cell Type: | esophageal squamous cell carcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq, CUT&Tag, ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | POLR2A |
About TF
| TF name : | BCLAF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| BCLAF1 | Kaposi sarcoma-associated herpesvirus | mirtarbase | 13 |
| BCLAF1 | Hs_Interactome_of_polycomb_repressive_complex_2_(PRC2)_WP2916_88672 | wikipathways | 15 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer