About Enhancer
| Enhancer ID: | E_01585 |
| Species: | Homo sapiens |
| Position : | chr6:31350000-31355000   |
| Year: | 2025 |
| Title: | Super-Enhancer-Driven HCG20 Promotes Pulmonary Hypertension Through U2AF2 Splicing |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40433695 |
| MONDO: | |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Human Pulmonary Artery Endothelial Cells |
| CVCL ID: | |
| Cell Type: | pulmonary artery endothelial cell |
| Cell Ontology ID: | CL:1001567 |
| Experiment Type: | Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, CRISPR Knockout, RT-RT-qPCR |
About Target Gene
| Target gene : | HCG20 |
About TF
| TF name : | USF2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| USF2 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer