About Enhancer
| Enhancer ID: | E_01593 |
| Species: | Homo sapiens |
| Position : | chr5:1230131-1231631   |
| Year: | 2025 |
| Title: | Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40404660 |
| MONDO: | |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | iPSC-derived excitatory neurons |
| CVCL ID: | |
| Cell Type: | excitatory neuron |
| Cell Ontology ID: | CL:0000540 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, Transgenic Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | LACZ |
About TF
| TF name : | NFYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFYB | Activation of gene expression by SREBF (SREBP) | reactome | 42 |
| NFYB | ATF4 activates genes | reactome | 25 |
| NFYB | ATF6-alpha activates chaperone genes | reactome | 10 |
| NFYB | Direct p53 effectors | pid | 141 |
| NFYB | PPARA activates gene expression | reactome | 113 |
| NFYB | TGF_beta_Receptor | netpath | 220 |
| NFYB | Validated targets of C-MYC transcriptional repression | pid | 63 |
| NFYB | Antigen processing and presentation | kegg | 75 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer