About Enhancer
| Enhancer ID: | E_01616 |
| Species: | Homo sapiens |
| Position : | chr5:171390000-171400000   |
| Year: | 2024 |
| Title: | Super-enhancer-driven FOSL1-TCOF1 axis promotes triple-negative breast cancer progression |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 39012147 |
| MONDO: | MONDO:0006120 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MDA-MB-231 |
| CVCL ID: | CVCL_0062 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, qRT-PCR, Western blot |
About Target Gene
| Target gene : | TCOF1 |
About TF
| TF name : | FOSL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOSL1 | AP-1 transcription factor network | pid | 71 |
| FOSL1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| FOSL1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| FOSL1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| FOSL1 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOSL1 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOSL1 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOSL1 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOSL1 | TGF-beta signaling pathway | panther | 88 |
| FOSL1 | Validated targets of C-MYC transcriptional activation | pid | 80 |
| FOSL1 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| FOSL1 | Wnt signaling pathway | kegg | 135 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer