About Enhancer
| Enhancer ID: | E_01631 |
| Species: | Homo sapiens |
| Position : | chr12:57092763-57094763   |
| Year: | 2017 |
| Title: | Extensive and functional overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte derived differentiating macrophages |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 28774779 |
| MONDO: | |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Monocyte-derived macrophages |
| CVCL ID: | |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | Enhancer cistrome analysis, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | 3C, RT-RT-qPCR |
About Target Gene
| Target gene : | STAT6 |
About TF
| TF name : | STAT6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| STAT6 | Downstream signal transduction | reactome | 29 |
| STAT6 | EGF receptor signaling pathway | panther | 109 |
| STAT6 | Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 14 |
| STAT6 | Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| STAT6 | Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| STAT6 | IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) | inoh | 10 |
| STAT6 | IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) | inoh | 7 |
| STAT6 | IL12-mediated signaling events | pid | 62 |
| STAT6 | IL4-mediated signaling events | pid | 66 |
| STAT6 | IL4 | netpath | 75 |
| STAT6 | IL9 | netpath | 24 |
| STAT6 | Interleukin signaling pathway | panther | 86 |
| STAT6 | JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 97 |
| STAT6 | JAK/STAT signaling pathway | panther | 15 |
| STAT6 | PDGF signaling pathway | panther | 113 |
| STAT6 | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 178 |
| STAT6 | Signaling events mediated by TCPTP | pid | 40 |
| STAT6 | TSLP | netpath | 24 |
| STAT6 | Jak-STAT signaling pathway | kegg | 149 |
| STAT6 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
| STAT6 | Hs_Cytokines_and_Inflammatory_Response_WP530_79331 | wikipathways | 21 |
| STAT6 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
| STAT6 | Hs_G1_to_S_cell_cycle_control_WP45_80001 | wikipathways | 8 |
| STAT6 | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer