About Enhancer
| Enhancer ID: | E_01631 |
| Species: | Mus musculus |
| Position : | chr2:24942670-24943220   |
| Year: | 2018 |
| Title: | The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | anaphylaxis |
| PMID: | 29277702 |
| MONDO: | MONDO:0100053 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | bone marrow-derived mast cells |
| Cell Type: | mast cell |
| Cell Ontology ID: | CL:0000097 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay; Endogenous enhancer perturbation; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | H3K4me1 ChIP-seq; H3K27ac ChIP-seq; ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; MITF-binding-site mutagenesis; ChIP-qPCR; shRNA knockdown; RT-qPCR; passive systemic anaphylaxis assay; ChIP; Mouse genetic deletion/knock-in; In vivo phenotyping |
About Target Gene
| Target gene : | Hdc |
About TF
| TF name : | Gata2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata2 | AP-1 transcription factor network | pid | 71 |
| Gata2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata2 | HIF-1-alpha transcription factor network | pid | 67 |
| Gata2 | IL3 | netpath | 84 |
| Gata2 | Regulation of Androgen receptor activity | pid | 54 |
| Gata2 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata2 | Signaling events mediated by HDAC Class II | pid | 58 |
| Gata2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01632 | chr2:24942670-24943220 | bone marrow | mast cell | anaphylaxis |
Expression of Target Genes for the Enhancer