About Enhancer
| Enhancer ID: | E_01632 |
| Species: | Homo sapiens |
| Position : | chr5:1294000-1297400   |
| Year: | 2023 |
| Title: | A genomic enhancer signature associates with hepatocellular carcinoma prognosis |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 37168287 |
| MONDO: | MONDO:0007256 |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HCC cells |
| CVCL ID: | |
| Cell Type: | hepatocellular carcinoma cell |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR |
About Target Gene
| Target gene : | TERT |
About TF
| TF name : | HNF4A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HNF4A | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| HNF4A | HIF-1-alpha transcription factor network | pid | 67 |
| HNF4A | Nuclear Receptor transcription pathway | reactome | 51 |
| HNF4A | Regulation of gene expression in beta cells | reactome | 17 |
| HNF4A | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| HNF4A | TGF_beta_Receptor | netpath | 220 |
| HNF4A | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01666 | chr5:1230131-1337133 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer