About Enhancer
| Enhancer ID: | E_01633 |
| Species: | Mus musculus |
| Position : | chr2:126627537-126628771   |
| Year: | 2018 |
| Title: | The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | anaphylaxis |
| PMID: | 29277702 |
| MONDO: | MONDO:0100053 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | bone marrow-derived mast cells |
| Cell Type: | mast cell |
| Cell Ontology ID: | CL:0000097 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay; Endogenous enhancer perturbation; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | H3K4me1 ChIP-seq; H3K27ac ChIP-seq; ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; MITF-binding-site mutagenesis; ChIP-qPCR; shRNA knockdown; RT-qPCR; passive systemic anaphylaxis assay; ChIP; Mouse genetic deletion/knock-in; In vivo phenotyping |
About Target Gene
| Target gene : | Hdc |
About TF
| TF name : | Mitf |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Mitf | IL6-mediated signaling events | pid | 48 |
| Mitf | KitReceptor | netpath | 104 |
| Mitf | RANKL | netpath | 84 |
| Mitf | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Mitf | Regulation of retinoblastoma protein | pid | 67 |
| Mitf | Signaling events mediated by Stem cell factor receptor (c-Kit) | pid | 53 |
| Mitf | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Mitf | SUMOylation of transcription factors | reactome | 14 |
| Mitf | Melanogenesis | kegg | 100 |
| Mitf | Pathways in cancer | kegg | 321 |
| Mitf | Melanoma | kegg | 69 |
| Mitf | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| Mitf | Hs_Kit_receptor_signaling_pathway_WP304_78799 | wikipathways | 46 |
| Mitf | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer