About Enhancer
| Enhancer ID: | E_01670 |
| Species: | Homo sapiens |
| Position : | chr1:152019738-152021345   |
| Year: | 2025 |
| Title: | ER stress upregulates S100A11 in steatohepatitis models via epigenetic modifications within the lipotoxicity-influenced enhancer |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 41027000 |
| MONDO: | MONDO:0007256 |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Huh7 cells |
| CVCL ID: | CVCL_0336 |
| Cell Type: | hepatocellular carcinoma cell |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | RNA-seq, ATAC-seq |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | S100A11 |
About TF
| TF name : | XBP1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| XBP1 | ATF6-alpha activates chaperone genes | reactome | 10 |
| XBP1 | FOXA1 transcription factor network | pid | 45 |
| XBP1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| XBP1 | XBP1(S) activates chaperone genes | reactome | 53 |
| XBP1 | Protein processing in endoplasmic reticulum | kegg | 166 |
| XBP1 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer