About Enhancer
| Enhancer ID: | E_01728 |
| Species: | Mus musculus |
| Position : | chr5:28561915-28564905   |
| Year: | 2014 |
| Title: | A novel regulatory element for Shh expression in the lung and gut of mouse embryos. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24157522 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Colon Adenocarcinoma Cell Lines |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 3C |
About Target Gene
| Target gene : | Shh |
About TF
| TF name : | Socs1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Socs1 | Antigen processing: Ubiquitination & Proteasome degradation | reactome | 260 |
| Socs1 | EGFR1 | netpath | 475 |
| Socs1 | Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 14 |
| Socs1 | Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| Socs1 | Growth hormone receptor signaling | reactome | 24 |
| Socs1 | Growth hormone signaling pathway(JAK2 STAT5) ( Growth hormone signaling(JAK2 STAT5) ) | inoh | 9 |
| Socs1 | IFN-gamma pathway | pid | 43 |
| Socs1 | IL12-mediated signaling events | pid | 62 |
| Socs1 | IL2-mediated signaling events | pid | 54 |
| Socs1 | IL2 | netpath | 81 |
| Socs1 | IL4-mediated signaling events | pid | 66 |
| Socs1 | IL4 | netpath | 75 |
| Socs1 | IL5 | netpath | 59 |
| Socs1 | Interferon alpha/beta signaling | reactome | 67 |
| Socs1 | Interferon gamma signaling | reactome | 88 |
| Socs1 | JAK degradation signaling ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 5 |
| Socs1 | JAK/STAT signaling pathway | panther | 15 |
| Socs1 | KitReceptor | netpath | 104 |
| Socs1 | MyD88:Mal cascade initiated on plasma membrane | reactome | 19 |
| Socs1 | Prolactin | netpath | 105 |
| Socs1 | Regulation of IFNA signaling | reactome | 26 |
| Socs1 | Regulation of IFNG signaling | reactome | 14 |
| Socs1 | Regulation of KIT signaling | reactome | 16 |
| Socs1 | Signaling events mediated by Stem cell factor receptor (c-Kit) | pid | 53 |
| Socs1 | TSH | netpath | 82 |
| Socs1 | Jak-STAT signaling pathway | kegg | 149 |
| Socs1 | Insulin signaling pathway | kegg | 134 |
| Socs1 | Type II diabetes mellitus | kegg | 44 |
| Socs1 | Toxoplasmosis | kegg | 131 |
| Socs1 | Hs_Interferon_type_I_signaling_pathways_WP585_85198 | wikipathways | 35 |
| Socs1 | Hs_Regulation_of_toll-like_receptor_signaling_pathway_WP1449_81172 | wikipathways | 47 |
| Socs1 | Hs_Fatty_Acid_Beta_Oxidation_WP143_79783 | wikipathways | 14 |
| Socs1 | Hs_Kit_receptor_signaling_pathway_WP304_78799 | wikipathways | 46 |
| Socs1 | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer