About Enhancer
| Enhancer ID: | E_01734 |
| Species: | Homo sapiens |
| Position : | chr9:5451500-5451650   |
| Year: | 2024 |
| Title: | Germline PDCD1 and CD274 variants modulate clinical outcomes and immune-related adverse events in NSCLC patients treated with immune checkpoint inhibitors |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | non-small cell lung carcinoma |
| PMID: | 38404767 |
| MONDO: | MONDO:0005233 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | NSCLC cell lines |
| CVCL ID: | |
| Cell Type: | non-small cell lung carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, EMSA |
About Target Gene
| Target gene : | CD274 |
About TF
| TF name : | CEBPA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CEBPA | AndrogenReceptor | netpath | 167 |
| CEBPA | C-MYB transcription factor network | pid | 87 |
| CEBPA | E2F transcription factor network | pid | 77 |
| CEBPA | EGFR1 | netpath | 475 |
| CEBPA | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| CEBPA | IL4 | netpath | 75 |
| CEBPA | Regulation of Androgen receptor activity | pid | 54 |
| CEBPA | Regulation of retinoblastoma protein | pid | 67 |
| CEBPA | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| CEBPA | Validated targets of C-MYC transcriptional repression | pid | 63 |
| CEBPA | Pathways in cancer | kegg | 321 |
| CEBPA | Acute myeloid leukemia | kegg | 53 |
| CEBPA | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 |
| CEBPA | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| CEBPA | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| CEBPA | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01397 | chr9:5450500-5452500 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_01398 | chr9:5450500-5452500 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_01399 | chr9:5450500-5452500 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_01400 | chr9:5450500-5452500 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer