About Enhancer
| Enhancer ID: | E_01735 |
| Species: | Homo sapiens |
| Position : | chr7:27089386-27207428   |
| Year: | 2025 |
| Title: | Epigenetic remodeling and 3D chromatin reorganization governed by NKX2-1 drive neuroendocrine prostate cancer |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 40765356 |
| MONDO: | MONDO:0008315 |
| Tissue: | Prostate |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | LuNE |
| CVCL ID: | |
| Cell Type: | prostate carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Western blot, qRT-PCR, CCK-8 Assay |
About Target Gene
| Target gene : | HOXA1 |
About TF
| TF name : | FOXA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA2 | FOXA1 transcription factor network | pid | 45 |
| FOXA2 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA2 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| FOXA2 | Regulation of gene expression in beta cells | reactome | 17 |
| FOXA2 | Maturity onset diabetes of the young | kegg | 25 |
| FOXA2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| FOXA2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| FOXA2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| FOXA2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01317 | chr7:27200782-27261018 | Bone marrow | acute monocytic leukemia cell | acute monocytic leukemia |
Expression of Target Genes for the Enhancer