About Enhancer
| Enhancer ID: | E_01751 |
| Species: | Homo sapiens |
| Position : | chr1:234567000-234577000   |
| Year: | 2025 |
| Title: | Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40132669 |
| MONDO: | |
| Tissue: | Liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Macrophages |
| CVCL ID: | |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | CUT&Tag, RNA-seq |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR |
About Target Gene
| Target gene : | PPP2R5A |
About TF
| TF name : | TLE3 |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TLE3 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| TLE3 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TLE3 | Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 21 |
| TLE3 | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| TLE3 | Repression of WNT target genes | reactome | 14 |
| TLE3 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| TLE3 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| TLE3 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| TLE3 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TLE3 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| TLE3 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TLE3 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| TLE3 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| TLE3 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| TLE3 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TLE3 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| TLE3 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TLE3 | Wnt signaling pathway | panther | 250 |
| TLE3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer