About Enhancer
| Enhancer ID: | E_01804 |
| Species: | Mus musculus |
| Position : | chr17:31939569-31956756   |
| Year: | 2015 |
| Title: | Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. |
| Genome Build: | mm9 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 25801169 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | mouse embryonic stem cells |
| Cell Type: | embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Super-enhancer profiling; Enhancer activity assay; Functional constituent perturbation assay |
| High Throughput Method: | POU5F1/SOX2/NANOG/MED1 ChIP-seq data integration; H3K27ac ChIP-seq; gene-expression profiling |
| Low Throughput Method: | Constituent luciferase reporter assays; OCT4 shutdown; CRISPR/Cas9 constituent enhancer deletion; RT-qPCR |
About Target Gene
| Target gene : | Sik1 |
About TF
| TF name : | Sox2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Sox2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Sox2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Sox2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Sox2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| Sox2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Sox2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer