About Enhancer
| Enhancer ID: | E_01839 |
| Species: | Homo sapiens |
| Position : | chr1:155100545-155103815   |
| Year: | 2025 |
| Title: | Super-enhancer-driven EFNA1 fuels tumor progression in cervical cancer via the FOSL2-Src/AKT/STAT3 axis |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | thyroid carcinoma |
| PMID: | 39964764 |
| MONDO: | MONDO:0005075 |
| Tissue: | Thyroid |
| Tissue Ontology ID: | UBERON:0002046 |
| Cell Source: | TPC1 |
| CVCL ID: | CVCL_6298 |
| Cell Type: | thyroid carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, CRISPRi, ChIP-RT-qPCR |
About Target Gene
| Target gene : | EFNA1 |
About TF
| TF name : | FOSL2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOSL2 | AP-1 transcription factor network | pid | 71 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOSL2 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| FOSL2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer