About Enhancer
| Enhancer ID: | E_01842 |
| Species: | Homo sapiens |
| Position : | chr3:15768491-15768703   |
| Year: | 2025 |
| Title: | Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2-Mediated Transcriptional Network in Multiple Myeloma |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40167268 |
| MONDO: | |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | CD34+ HSPCs |
| CVCL ID: | |
| Cell Type: | hematopoietic stem and progenitor cell |
| Cell Ontology ID: | CL:0008001 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, CUT&Tag |
| Low Throughput Method: | CRISPR knockout, CRISPRi, ChIP-RT-qPCR, FISH |
About Target Gene
| Target gene : | IRF4 |
About TF
| TF name : | POU2F2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F2 | BCR signaling pathway | pid | 70 |
| POU2F2 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01570 | chr3:15768491-15768703 | Blood | plasma cell | multiple myeloma |
| E_01571 | chr3:15768491-15768703 | Blood | plasma cell | multiple myeloma |
| E_01572 | chr3:15768491-15768703 | Blood | plasma cell | multiple myeloma |
| E_01573 | chr3:15768491-15768703 | Blood | plasma cell | multiple myeloma |
Expression of Target Genes for the Enhancer