About Enhancer
| Enhancer ID: | E_01854 |
| Species: | Mus musculus |
| Position : | chr1:13041306-13127367   |
| Year: | 2015 |
| Title: | Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 25801169 |
| Cell Source: | Embryonic Stem Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Endogenous enhancer perturbation |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | Prdm14 |
About TF
| TF name : | Sox2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Sox2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Sox2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Sox2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Sox2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| Sox2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Sox2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01852 | chr1:13041306-13127367 | NA | NA | NA |
| E_01853 | chr1:13041306-13127367 | NA | NA | NA |
| E_01557 | chr1:13072129-13076981 | embryo | primordial germ cell-like cell | NA |
| E_01558 | chr1:13072129-13076981 | embryo | epiblast-like cell | NA |
| E_01540 | chr1:13084831-13085465 | embryo | embryonic stem cell | NA |
| E_01559 | chr1:13084831-13085465 | embryo | primordial germ cell-like cell | NA |
| E_01541 | chr1:13093655-13096290 | embryo | embryonic stem cell | NA |
| E_01560 | chr1:13093655-13096290 | embryo | primordial germ cell-like cell | NA |
| E_01561 | chr1:13093655-13096290 | embryo | epiblast-like cell | NA |
| E_03578 | chr1:13093655-13096290 | embryo | epiblast cell | NA |
Expression of Target Genes for the Enhancer