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Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_01881
Species: Homo sapiens
Position : chr18:47901736-47902193
Year: 2023
Title: Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
Genome Build: hg38
Enhancer Type: Enhancer
Condition: Normal
Disease Name: --
PMID:  37488417
MONDO:
Tissue: Inner cell mass
Tissue Ontology ID: UBERON:0000087
Cell Source: HUES8 human embryonic stem cell line
CVCL ID: CVCL_2063
Cell Type: embryonic stem cell
Cell Ontology ID: CL:0002322
Experiment Type: CRISPR interference-based functional screen
High Throughput Method: CRISPRi screen, RNA-seq, ATAC-seq, ChIP-seq, Hi-C
Low Throughput Method: RT-qPCR, flow cytometry, FACS
About Target Gene
Target gene : SMAD2
About TF
TF name : SMAD2SMAD4JUN
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
SMAD2 Alpha6Beta4Integrin netpath 74
SMAD2 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 34
SMAD2 Downregulation of SMAD2/3:SMAD4 transcriptional activity reactome 23
SMAD2 Downregulation of TGF-beta receptor signaling reactome 26
SMAD2 EGFR1 netpath 475
SMAD2 Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 8
SMAD2 Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 7
SMAD2 Glypican 1 network pid 26
SMAD2 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 21
SMAD2 Regulation of cytoplasmic and nuclear SMAD2/3 signaling pid 20
SMAD2 Regulation of nuclear SMAD2/3 signaling pid 82
SMAD2 Signaling by Activin reactome 11
SMAD2 Signaling by NODAL reactome 19
SMAD2 SMAD2/3 MH2 Domain Mutants in Cancer reactome 7
SMAD2 SMAD2/3 Phosphorylation Motif Mutants in Cancer reactome 6
SMAD2 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription reactome 32
SMAD2 SnoN degradation signaling ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 38
SMAD2 TGF-beta receptor signaling activates SMADs reactome 12
SMAD2 TGF-beta receptor signaling pid 53
SMAD2 TGF-beta signaling pathway panther 88
SMAD2 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 51
SMAD2 TGF_beta_Receptor netpath 220
SMAD2 TGFBR1 KD Mutants in Cancer reactome 7
SMAD2 TNFalpha netpath 274
SMAD2 Transcriptional regulation of pluripotent stem cells reactome 28
SMAD2 Validated targets of C-MYC transcriptional repression pid 63
SMAD2 Cell cycle kegg 124
SMAD2 Endocytosis kegg 201
SMAD2 Wnt signaling pathway kegg 135
SMAD2 TGF-beta signaling pathway kegg 82
SMAD2 Adherens junction kegg 70
SMAD2 Chagas disease kegg 103
SMAD2 Pathways in cancer kegg 321
SMAD2 Colorectal cancer kegg 63
SMAD2 Pancreatic cancer kegg 70
SMAD2 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
SMAD2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
SMAD2 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
SMAD2 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
SMAD2 Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
SMAD4 ALK1 signaling events pid 26
SMAD4 ALK2 signaling events pid 11
SMAD4 BMP receptor signaling pid 42
SMAD4 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 34
SMAD4 BMP Signalling Pathway humancyc 5
SMAD4 BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 13
SMAD4 Downregulation of SMAD2/3:SMAD4 transcriptional activity reactome 23
SMAD4 Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 8
SMAD4 Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 7
SMAD4 HIF-1-alpha transcription factor network pid 67
SMAD4 LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) inoh 10
SMAD4 LKB1 signaling events pid 43
SMAD4 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 21
SMAD4 Regulation of cytoplasmic and nuclear SMAD2/3 signaling pid 20
SMAD4 Regulation of nuclear SMAD2/3 signaling pid 82
SMAD4 Signaling by Activin reactome 11
SMAD4 Signaling by BMP reactome 23
SMAD4 Signaling by NODAL reactome 19
SMAD4 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
SMAD4 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
SMAD4 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
SMAD4 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
SMAD4 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
SMAD4 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
SMAD4 Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 19
SMAD4 SMAD2/3 MH2 Domain Mutants in Cancer reactome 7
SMAD4 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription reactome 32
SMAD4 TGF-beta receptor signaling activates SMADs reactome 12
SMAD4 TGF-beta receptor signaling pid 53
SMAD4 TGF-beta signaling pathway panther 88
SMAD4 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 51
SMAD4 TGF_beta_Receptor netpath 220
SMAD4 Transcriptional regulation of pluripotent stem cells reactome 28
SMAD4 Validated nuclear estrogen receptor alpha network pid 65
SMAD4 Validated targets of C-MYC transcriptional activation pid 80
SMAD4 Validated targets of C-MYC transcriptional repression pid 63
SMAD4 Wnt signaling pathway panther 250
SMAD4 Cell cycle kegg 124
SMAD4 Wnt signaling pathway kegg 135
SMAD4 TGF-beta signaling pathway kegg 82
SMAD4 Adherens junction kegg 70
SMAD4 Pathways in cancer kegg 321
SMAD4 Colorectal cancer kegg 63
SMAD4 Pancreatic cancer kegg 70
SMAD4 Chronic myeloid leukemia kegg 69
SMAD4 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
SMAD4 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
SMAD4 Hs_Heart_Development_WP1591_90186 wikipathways 28
SMAD4 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
SMAD4 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
SMAD4 Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
JUN Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
JUN Activation of the AP-1 family of transcription factors reactome 10
JUN Alpha6Beta4Integrin netpath 74
JUN AndrogenReceptor netpath 167
JUN Angiogenesis panther 141
JUN AP-1 transcription factor network pid 71
JUN Apoptosis signaling pathway panther 104
JUN ATF-2 transcription factor network pid 59
JUN B cell activation panther 52
JUN BCR netpath 161
JUN BCR signaling pathway pid 70
JUN Calcineurin-regulated NFAT-dependent transcription in lymphocytes pid 50
JUN Calcium signaling in the CD4+ TCR pathway pid 29
JUN CD40/CD40L signaling pid 36
JUN CDC42 signaling events pid 71
JUN Direct p53 effectors pid 141
JUN Downstream signaling in naïve CD8+ T cells pid 69
JUN EGFR1 netpath 475
JUN Endothelins pid 64
JUN ErbB1 downstream signaling pid 105
JUN ErbB2/ErbB3 signaling events pid 41
JUN FAS signaling pathway panther 37
JUN Fc-epsilon receptor I signaling in mast cells pid 64
JUN FCERI mediated MAPK activation reactome 40
JUN FGF signaling pathway pid 55
JUN FOXA1 transcription factor network pid 45
JUN Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) inoh 5
JUN Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) inoh 5
JUN Glucocorticoid receptor regulatory network pid 85
JUN HIF-1-alpha transcription factor network pid 67
JUN Huntington disease panther 113
JUN IL1-mediated signaling events pid 34
JUN IL1 netpath 69
JUN IL12 signaling mediated by STAT4 pid 33
JUN IL2-mediated signaling events pid 54
JUN IL2 netpath 81
JUN IL5 netpath 59
JUN IL6-mediated signaling events pid 48
JUN IL6 netpath 85
JUN Inflammation mediated by chemokine and cytokine signaling pathway panther 189
JUN Integrin-linked kinase signaling pid 46
JUN Intracellular Signalling Through Adenosine Receptor A2a and Adenosine smpdb 37
JUN Intracellular Signalling Through Adenosine Receptor A2b and Adenosine smpdb 38
JUN JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) inoh 12
JUN JNK cascade ( CD4 T cell receptor signaling ) inoh 10
JUN JNK cascade ( TGF-beta signaling(through TAK1) ) inoh 6
JUN JNK cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ) inoh 12
JUN JNK signaling in the CD4+ TCR pathway pid 14
JUN KitReceptor netpath 104
JUN LPA receptor mediated events pid 65
JUN MAPK6/MAPK4 signaling reactome 90
JUN Nephrin/Neph1 signaling in the kidney podocyte pid 28
JUN Osteopontin-mediated events pid 32
JUN Oxidative Stress Induced Senescence reactome 120
JUN Oxidative stress response panther 23
JUN PDGF signaling pathway panther 113
JUN PDGFR-alpha signaling pathway pid 22
JUN PDGFR-beta signaling pathway pid 125
JUN Pre-NOTCH Transcription and Translation reactome 29
JUN Presenilin action in Notch and Wnt signaling pid 46
JUN Prolactin netpath 105
JUN RAC1 signaling pathway pid 54
JUN RANKL netpath 84
JUN Ras Pathway panther 69
JUN Regulation of Androgen receptor activity pid 54
JUN Regulation of nuclear beta catenin signaling and target gene transcription pid 80
JUN Regulation of nuclear SMAD2/3 signaling pid 82
JUN Regulation of retinoblastoma protein pid 67
JUN Regulation of Telomerase pid 70
JUN RhoA signaling pathway pid 46
JUN S1P2 pathway pid 26
JUN Senescence-Associated Secretory Phenotype (SASP) reactome 108
JUN Signaling events mediated by focal adhesion kinase pid 63
JUN Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) pid 80
JUN Signaling events regulated by Ret tyrosine kinase pid 39
JUN Signaling mediated by p38-alpha and p38-beta pid 35
JUN T cell activation panther 60
JUN TCR netpath 261
JUN TGF-beta signaling pathway panther 88
JUN TGF_beta_Receptor netpath 220
JUN TNFalpha netpath 274
JUN Toll receptor signaling pathway panther 44
JUN TP53 Regulates Transcription of DNA Repair Genes reactome 61
JUN Validated nuclear estrogen receptor alpha network pid 65
JUN Validated transcriptional targets of AP1 family members Fra1 and Fra2 pid 37
JUN Wnt netpath 118
JUN JNK cascade ( IL-1 signaling pathway (through JNK cascade) ) inoh 16
JUN JNK cascade ( Toll-like receptor signaling pathway (through JNK cascade) ) inoh 12
JUN MAPK signaling pathway kegg 264
JUN ErbB signaling pathway kegg 83
JUN Wnt signaling pathway kegg 135
JUN Focal adhesion kegg 197
JUN Toll-like receptor signaling pathway kegg 100
JUN T cell receptor signaling pathway kegg 105
JUN B cell receptor signaling pathway kegg 70
JUN Neurotrophin signaling pathway kegg 126
JUN GnRH signaling pathway kegg 98
JUN Epithelial cell signaling in Helicobacter pylori infection kegg 67
JUN Leishmaniasis kegg 71
JUN Chagas disease kegg 103
JUN Pathways in cancer kegg 321
JUN Colorectal cancer kegg 63
JUN Renal cell carcinoma kegg 65
JUN Hs_MAPK_Signaling_Pathway_WP382_79951 wikipathways 58
JUN Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36
JUN Hs_Apoptosis_WP254_88977 wikipathways 31
JUN Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
JUN Hs_T-Cell_antigen_Receptor_(TCR)_pathway_during_Staphylococcus_aureus_infection_WP3863_90702 wikipathways 35
JUN Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293 wikipathways 71
JUN Hs_PDGF_Pathway_WP2526_82681 wikipathways 12
JUN Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
JUN Hs_ATM_Signaling_Pathway_WP2516_90247 wikipathways 32
JUN Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 wikipathways 11
JUN Hs_Nucleotide_Metabolism_WP404_68960 wikipathways 16
JUN Hs_TNF_alpha_Signaling_Pathway_WP231_89895 wikipathways 61
JUN Hs_Estrogen_signaling_pathway_WP712_78491 wikipathways 13
JUN Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
JUN Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
JUN Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
JUN Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
JUN Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 wikipathways 60
JUN Hs_IL-1_signaling_pathway_WP195_89932 wikipathways 34
JUN Hs_IL-3_Signaling_Pathway_WP286_78583 wikipathways 35
JUN Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 wikipathways 71
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer