About Enhancer
| Enhancer ID: | E_01949 |
| Species: | Mus musculus |
| Position : | chr1:133308997-133319722   |
| Year: | 2015 |
| Title: | Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in mice. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25486239 |
| Tissue: | hypothalamus |
| Tissue Ontology ID: | UBERON:0001898 |
| Cell Source: | primary arcuate nucleus kisspeptin neurons |
| Cell Type: | kisspeptin neuron |
| Cell Ontology ID: | CL:4023130 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; In vivo reporter assay; In vivo functional validation |
| Low Throughput Method: | Transgenic GFP reporter assay; 5-prime deletion analysis; ESR1 ChIP-PCR; 3C; immunofluorescence; kisspeptin/GFP colocalization; ChIP; In vivo phenotyping; Reporter assay |
About Target Gene
| Target gene : | Kiss1 |
About TF
| TF name : | Esr1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Esr1 | AndrogenReceptor | netpath | 167 |
| Esr1 | AP-1 transcription factor network | pid | 71 |
| Esr1 | ATF-2 transcription factor network | pid | 59 |
| Esr1 | Cellular roles of Anthrax toxin | pid | 25 |
| Esr1 | FOXA1 transcription factor network | pid | 45 |
| Esr1 | FOXM1 transcription factor network | pid | 43 |
| Esr1 | Leptin | netpath | 98 |
| Esr1 | LKB1 signaling events | pid | 43 |
| Esr1 | Nuclear Receptor transcription pathway | reactome | 51 |
| Esr1 | Nuclear signaling by ERBB4 | reactome | 25 |
| Esr1 | Plasma membrane estrogen receptor signaling | pid | 42 |
| Esr1 | Prolactin | netpath | 105 |
| Esr1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Esr1 | Regulation of Telomerase | pid | 70 |
| Esr1 | Signaling events mediated by HDAC Class II | pid | 58 |
| Esr1 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Esr1 | Tamoxifen Action Pathway | smpdb | 10 |
| Esr1 | Tamoxifen Metabolism Pathway | smpdb | 10 |
| Esr1 | TGF_beta_Receptor | netpath | 220 |
| Esr1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| Esr1 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 |
| Esr1 | Hs_Leptin_signaling_pathway_WP2034_89856 | wikipathways | 37 |
| Esr1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| Esr1 | Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 | wikipathways | 16 |
| Esr1 | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01950 | chr1:133303739-133325138 | NA | NA | NA |
Expression of Target Genes for the Enhancer