About Enhancer
| Enhancer ID: | E_01959 |
| Species: | Homo sapiens |
| Position : | chr14:97720000-97780000   |
| Year: | 2007 |
| Title: | Activation of TLX3 and NKX2-5 in t(5;14)(q35;q322) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU1 and HMGA1 |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 17308084 |
| MONDO: | MONDO:0004947 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | HPB-ALL |
| CVCL ID: | CVCL_1921 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | DNase-seq |
| Low Throughput Method: | DNA inhibitory treatment, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, FISH |
About Target Gene
| Target gene : | NKX2-5 |
About TF
| TF name : | PU.1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01957 | chr14:97720000-97780000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01958 | chr14:97720000-97780000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01960 | chr14:97720000-97780000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01961 | chr14:97720000-97780000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01962 | chr14:97720000-97780000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01963 | chr14:97720000-97780000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01964 | chr14:97720000-97780000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer