About Enhancer
| Enhancer ID: | E_01959 |
| Species: | Mus musculus |
| Position : | chr12:114182511-114183025   |
| Year: | 2023 |
| Title: | An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36869028 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary pro-B cells / EVH1-mutant mouse |
| Cell Type: | pro-B cell |
| Cell Ontology ID: | CL:0000826 |
| Experiment Type: | Enhancer activity; TF occupancy; chromatin-conformation and V(D)J functional perturbation |
| High Throughput Method: | Hi-C; H3K27ac/H3K4me1 ChIP-seq; ATAC-seq; RNA-seq; V(D)J-seq |
| Low Throughput Method: | CRISPR enhancer deletion; 3C/4C; V(D)J recombination qPCR; ChIP-qPCR; DNA FISH |
About Target Gene
| Target gene : | Igh |
About TF
| TF name : | Tcf3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf3 | CDO in myogenesis | reactome | 29 |
| Tcf3 | ID | netpath | 38 |
| Tcf3 | Notch-mediated HES/HEY network | pid | 48 |
| Tcf3 | Notch | netpath | 76 |
| Tcf3 | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| Tcf3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Tcf3 | Wnt | netpath | 118 |
| Tcf3 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer