About Enhancer
| Enhancer ID: | E_01967 |
| Species: | Mus musculus |
| Position : | chr7:103852766-103877545   |
| Year: | 2017 |
| Title: | LDB1-mediated enhancer looping can be established independent of mediator and cohesin. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 28520978 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MEL mouse erythroleukemia cells |
| Cell Type: | erythroid cell |
| Experiment Type: | Chromatin interaction assay; Enhancer-promoter looping perturbation assay |
| High Throughput Method: | ENCODE ChIP-seq/chromatin-state data integration |
| Low Throughput Method: | 3C; LDB1 knockdown/rescue; dCas9-LDB1 forced looping; ChIP-qPCR; RT-qPCR; Western blot; co-immunoprecipitation; CRISPR-Cas9 |
About Target Gene
| Target gene : | Hbb-bs |
About TF
| TF name : | Gata1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata1 | C-MYB transcription factor network | pid | 87 |
| Gata1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata1 | IL3 | netpath | 84 |
| Gata1 | Notch-mediated HES/HEY network | pid | 48 |
| Gata1 | p73 transcription factor network | pid | 80 |
| Gata1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer