About Enhancer
| Enhancer ID: | E_01971 |
| Species: | Mus musculus |
| Position : | chr6:50913170-51087888   |
| Year: | 2023 |
| Title: | A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 37277355 |
| Tissue: | pharyngeal arch |
| Tissue Ontology ID: | UBERON:0002539 |
| Cell Source: | E10.5 second pharyngeal arch cranial neural crest cells |
| Cell Type: | neural crest cell |
| Cell Ontology ID: | CL:0011012 |
| Experiment Type: | Enhancer activity assay; Chromatin interaction assay; Endogenous functional perturbation assay; TF occupancy analysis; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | Pbx ChIP-seq; H3K27ac ChIP-seq; ATAC-seq; Hi-C; PCHi-C; RNA-seq |
| Low Throughput Method: | CRISPR/Cas9 HIRE1 deletion; RT-qPCR; in situ hybridization; skeletal staining; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Hoxa2 |
About TF
| TF name : | Pbx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pbx1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Pbx1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Pbx1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01968 | chr6:50913170-51087888 | pharyngeal arch | neural crest cell | NA |
| E_01969 | chr6:50913170-51087888 | pharyngeal arch | neural crest cell | NA |
| E_01970 | chr6:50913170-51087888 | pharyngeal arch | neural crest cell | NA |
| E_01972 | chr6:50913170-51087888 | pharyngeal arch | neural crest cell | NA |
Expression of Target Genes for the Enhancer