About Enhancer
| Enhancer ID: | E_01991 |
| Species: | Homo sapiens |
| Position : | chr8:130180065-130180972   |
| Year: | 2014 |
| Title: | A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 25194570 |
| MONDO: | MONDO:0004963 |
| Tissue: | thymus |
| Tissue Ontology ID: | UBERON:0002370 |
| Cell Source: | CUTLL1 |
| CVCL ID: | CVCL_4966 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Long-range enhancer TF-binding and genetic validation |
| High Throughput Method: | NOTCH1 ChIP-seq; RBPJ ChIP-seq; chromatin interaction profiling |
| Low Throughput Method: | Reporter assay; N-Me knockout mouse; leukemia induction assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | RBPJ |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RBPJ | Alzheimer disease-presenilin pathway | panther | 98 |
| RBPJ | Angiogenesis | panther | 141 |
| RBPJ | Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 19 |
| RBPJ | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| RBPJ | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| RBPJ | Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 15 |
| RBPJ | NICD traffics to nucleus | reactome | 13 |
| RBPJ | Notch-HLH transcription pathway | reactome | 13 |
| RBPJ | Notch-mediated HES/HEY network | pid | 48 |
| RBPJ | Notch | netpath | 76 |
| RBPJ | Notch signaling pathway | panther | 27 |
| RBPJ | Notch signaling pathway | pid | 58 |
| RBPJ | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| RBPJ | NOTCH2 intracellular domain regulates transcription | reactome | 12 |
| RBPJ | Pre-NOTCH Transcription and Translation | reactome | 29 |
| RBPJ | Presenilin action in Notch and Wnt signaling | pid | 46 |
| RBPJ | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| RBPJ | Notch signaling pathway | kegg | 44 |
| RBPJ | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
67 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02010 | chr8:130179643-130181490 | blood / hematopoietic system | T cell | T-cell acute lymphoblastic leukemia |
| E_00455 | chr8:130180012-130180748 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01422 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01423 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01424 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01425 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01426 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01427 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01428 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01429 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01435 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01436 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01437 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01438 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01980 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01981 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01982 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01983 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01988 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01989 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01990 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01992 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01993 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01994 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01995 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01996 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01997 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01998 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01999 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02000 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_02001 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02002 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02003 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02007 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02008 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03525 | chr8:130180065-130180972 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03541 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03542 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03545 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03546 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03547 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03548 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03549 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03577 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_04520 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04526 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04527 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04528 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04529 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01368 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01369 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01414 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01415 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01416 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01417 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01418 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01419 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01420 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01421 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_03543 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03544 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03551 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03552 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03553 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03554 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04512 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04513 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer