About Enhancer
| Enhancer ID: | E_01999 |
| Species: | Mus musculus |
| Position : | chr12:114182511-114183025   |
| Year: | 2023 |
| Title: | An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 36869028 |
| MONDO: | |
| Tissue: | Spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Abl-transformed pro-B cells |
| CVCL ID: | |
| Cell Type: | pro-B cell |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Functional perturbation assay, Enhancer activity assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | Hi-C, ChIP-seq, RNA-seq, ATAC-seq, VDJ-seq, 3C-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, ChIP-RT-qPCR, 3C assay, 4C assay, FISH, Western blot |
About Target Gene
| Target gene : | Igh |
About TF
| TF name : | Ctcf |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ctcf | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Ctcf | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer