About Enhancer
| Enhancer ID: | E_02000 |
| Species: | Homo sapiens |
| Position : | chr8:130180065-130180972   |
| Year: | 2014 |
| Title: | A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 25194570 |
| MONDO: | MONDO:0004963 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | CUTLL1 |
| CVCL ID: | CVCL_4966 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Long-range enhancer functional validation; genetic enhancer requirement |
| High Throughput Method: | NOTCH1 ChIP-seq; H3K27ac enhancer profiling |
| Low Throughput Method: | luciferase reporter assay; enhancer-promoter interaction assay; N-Me knockout mice; leukemia transplantation and transformation assays |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NOTCH1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NOTCH1 | A third proteolytic cleavage releases NICD | reactome | 9 |
| NOTCH1 | Activated NOTCH1 Transmits Signal to the Nucleus | reactome | 30 |
| NOTCH1 | Alzheimer disease-presenilin pathway | panther | 98 |
| NOTCH1 | Angiogenesis | panther | 141 |
| NOTCH1 | C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 8 |
| NOTCH1 | Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 19 |
| NOTCH1 | Constitutive Signaling by NOTCH1 HD Domain Mutants | reactome | 15 |
| NOTCH1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| NOTCH1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| NOTCH1 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | reactome | 7 |
| NOTCH1 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | reactome | 5 |
| NOTCH1 | Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) | inoh | 15 |
| NOTCH1 | NICD traffics to nucleus | reactome | 13 |
| NOTCH1 | Notch-HLH transcription pathway | reactome | 13 |
| NOTCH1 | Notch-mediated HES/HEY network | pid | 48 |
| NOTCH1 | Notch | netpath | 76 |
| NOTCH1 | Notch degradation signaling ( Notch signaling pathway Diagram ) | inoh | 5 |
| NOTCH1 | Notch degradation signaling (Mammal) ( Notch signaling pathway Diagram ) | inoh | 5 |
| NOTCH1 | Notch secretory pathway ( Notch signaling pathway Diagram ) | inoh | 5 |
| NOTCH1 | Notch secretory pathway (C. elegans) ( Notch signaling pathway Diagram ) | inoh | 5 |
| NOTCH1 | Notch signaling pathway | panther | 27 |
| NOTCH1 | Notch signaling pathway | pid | 58 |
| NOTCH1 | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| NOTCH1 | Pre-NOTCH Processing in Golgi | reactome | 18 |
| NOTCH1 | Pre-NOTCH Processing in the Endoplasmic Reticulum | reactome | 6 |
| NOTCH1 | Pre-NOTCH Transcription and Translation | reactome | 29 |
| NOTCH1 | Presenilin action in Notch and Wnt signaling | pid | 46 |
| NOTCH1 | Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor | reactome | 14 |
| NOTCH1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| NOTCH1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| NOTCH1 | Dorso-ventral axis formation | kegg | 25 |
| NOTCH1 | Notch signaling pathway | kegg | 44 |
| NOTCH1 | Hs_Gastric_Cancer_Network_1_WP2361_86831 | wikipathways | 26 |
| NOTCH1 | Hs_PI3K-AKT-mTOR_signaling_pathway_and_therapeutic_opportunities_WP3844_89952 | wikipathways | 5 |
| NOTCH1 | Hs_Primary_Focal_Segmental_Glomerulosclerosis_FSGS_WP2572_90019 | wikipathways | 7 |
| NOTCH1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| NOTCH1 | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| NOTCH1 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| NOTCH1 | Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527 | wikipathways | 12 |
| NOTCH1 | Hs_Amplification_and_Expansion_of_Oncogenic_Pathways_as_Metastatic_Traits_WP3678_90110 | wikipathways | 5 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
67 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02010 | chr8:130179643-130181490 | blood / hematopoietic system | T cell | T-cell acute lymphoblastic leukemia |
| E_00455 | chr8:130180012-130180748 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01422 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01423 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01424 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01425 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01426 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01427 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01428 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01429 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01435 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01436 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01437 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01438 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01980 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01981 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01982 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01983 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01988 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01989 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01990 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01991 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01992 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01993 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01994 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01995 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01996 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01997 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01998 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01999 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02001 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02002 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02003 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02007 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02008 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03525 | chr8:130180065-130180972 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03541 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03542 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03545 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03546 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03547 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03548 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03549 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03577 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_04520 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04526 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04527 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04528 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04529 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01368 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01369 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01414 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01415 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01416 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01417 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01418 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01419 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01420 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01421 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_03543 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03544 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03551 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03552 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03553 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03554 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04512 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04513 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer