About Enhancer
| Enhancer ID: | E_02014 |
| Species: | Homo sapiens |
| Position : | chrX:16824570-16829407   |
| Year: | 2025 |
| Title: | Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 40038738 |
| MONDO: | MONDO:0004989 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | T-47D |
| CVCL ID: | CVCL_0553 |
| Cell Type: | mammary gland epithelial cell |
| Cell Ontology ID: | CL:0002327 |
| Experiment Type: | Super-enhancer activity assay; Histone modification assay; Functional perturbation assay |
| High Throughput Method: | Public H3K27ac ChIP-seq data analysis; Public EP300 ChIP-seq/DNase-seq data analysis; ROSE |
| Low Throughput Method: | CRISPR/Cas9-mediated super-enhancer deletion; H3K27ac ChIP-qPCR; EP300 ChIP-qPCR; p300 siRNA knockdown; RT-qPCR; Western blotting; JQ1 treatment; CCK-8 assay; Colony formation assay; Transwell assay; RBBP7 rescue; CRISPR-Cas9; Luciferase reporter assay; Reporter assay; ChIP-qPCR; qPCR |
About Target Gene
| Target gene : | RBBP7 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02013 | chrX:16824570-16829407 | breast | mammary gland epithelial cell | breast carcinoma |
Expression of Target Genes for the Enhancer