About Enhancer
| Enhancer ID: | E_02017 |
| Species: | Homo sapiens |
| Position : | chr7:55249000-55251000   |
| Year: | 2023 |
| Title: | Epigenomic perturbation of novel EGFR enhancers reduces the proliferative and invasive capacity of glioblastoma and increases sensitivity to temozolomide. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | glioblastoma |
| PMID: | 37803333 |
| MONDO: | MONDO:0018177 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | U-251MG |
| CVCL ID: | CVCL_0021 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; endogenous enhancer perturbation assay; Endogenous enhancer perturbation; Disease-variant functional analysis |
| High Throughput Method: | H3K27ac ChIP-seq; ATAC-seq; RNA-seq |
| Low Throughput Method: | CRISPRi dCas9-KRAB; CRISPR deletion; luciferase reporter assay; RT-qPCR; western blot; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | EGFR |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03278 | chr7:54978916-55304142 | breast | malignant cell | multiple cancer types |
Expression of Target Genes for the Enhancer