About Enhancer
| Enhancer ID: | E_02018 |
| Species: | Homo sapiens |
| Position : | chr8:128554145-128555945   |
| Year: | 2022 |
| Title: | Targeting of noncoding RNAs encoded by a novel MYC enhancers inhibits the proliferation of human hepatic carcinoma cells in vitro. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 35039581 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Huh-7 |
| CVCL ID: | CVCL_0336 |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay; enhancer RNA Functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | H3K27ac ChIP-seq; EP300 ChIP-seq; GRO-seq |
| Low Throughput Method: | Dual-luciferase reporter assay; ASO-mediated R2 eRNA inhibition; RT-qPCR; WST-1 assay; spheroid formation assay; CRISPR-Cas9 endogenous deletion/editing; Reporter assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03876 | chr8:126650000-129950000 | colon | malignant cell | NA |
Expression of Target Genes for the Enhancer