About Enhancer
| Enhancer ID: | E_02020 |
| Species: | Homo sapiens |
| Position : | chr1:16162175-16195191   |
| Year: | 2022 |
| Title: | A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | ovarian carcinoma |
| PMID: | 35869079 |
| MONDO: | MONDO:0005140 |
| Tissue: | ovary |
| Tissue Ontology ID: | UBERON:0000992 |
| Cell Source: | OVCAR-3 |
| CVCL ID: | CVCL_0465 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay; Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, RNA-seq, Hi-C, ATAC-seq, scATAC-seq, scRNA-seq; RNA-seq; Hi-C |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, qRT-PCR, Western blot, Cell Proliferation Assay, Cell Migration Assay |
About Target Gene
| Target gene : | EPHA2 |
About TF
| TF name : | ELF3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ELF3 | EGFR1 | netpath | 475 |
| ELF3 | PDGF signaling pathway | panther | 113 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00452 | chr1:16160379-16162282 | bone marrow | malignant cell | hematopoietic malignancy |
| E_00453 | chr1:16160379-16162282 | bone marrow | malignant cell | hematopoietic malignancy |
| E_00495 | chr1:16160379-16162282 | bone marrow | malignant cell | hematopoietic malignancy |
| E_00646 | chr1:16160379-16162282 | blood | NA | hematologic malignancy |
Expression of Target Genes for the Enhancer