About Enhancer
| Enhancer ID: | E_02024 |
| Species: | Homo sapiens |
| Position : | chr1:47677539-47677958   |
| Year: | 2020 |
| Title: | Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 32086528 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Chromatin interaction assay; Functional chromatin-architecture perturbation assay |
| High Throughput Method: | Chromatin accessibility and chromatin-conformation profiling; ChIP-seq; transcriptome profiling |
| Low Throughput Method: | CRISPR/Cas9 deletion/inversion of -31-kb CTCF boundary; chromatin-interaction validation; RT-qPCR; Western blot; leukemogenesis assay |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01480 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01481 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01482 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01483 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01505 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01506 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01468 | chr1:47677544-47677944 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01487 | chr1:47677544-47677944 | blood | T cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer