About Enhancer
| Enhancer ID: | E_02032 |
| Species: | Homo sapiens |
| Position : | chr6:396104-396604   |
| Year: | 2024 |
| Title: | Cell-type-directed design of synthetic enhancers. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | cutaneous melanoma |
| PMID: | 38086419 |
| MONDO: | MONDO:0005012 |
| Tissue: | zone of skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | Human melanoma cell |
| Cell Type: | melanoma cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay; CRISPRi; CRISPR Knockout; RT-RT-qPCR; ChIP-RT-qPCR |
About Target Gene
| Target gene : | IRF4 |
About TF
| TF name : | SOX10 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX10 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer