About Enhancer
| Enhancer ID: | E_02036 |
| Species: | Mus musculus |
| Position : | chr6:50913170-51087888   |
| Year: | 2023 |
| Title: | A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 37277355 |
| MONDO: | |
| Tissue: | Pharyngeal Arch |
| Tissue Ontology ID: | UBERON:0002539 |
| Cell Source: | Cranial neural crest cells |
| CVCL ID: | |
| Cell Type: | cranial neural crest cell |
| Cell Ontology ID: | CL:0000333 |
| Experiment Type: | Chromatin interaction assay, Functional perturbation assay, Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq, Hi-C, ATAC-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | Hoxa2 |
About TF
| TF name : | Hoxa2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Hoxa2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02032 | chr6:50913170-51087888 | Adipose Tissue | preadipocyte | -- |
| E_02038 | chr6:50913170-51087888 | Pharyngeal Arch | cranial neural crest cell | -- |
| E_02039 | chr6:50913170-51087888 | Pharyngeal Arch | cranial neural crest cell | -- |
| E_02040 | chr6:50913170-51087888 | Pituitary gland | gonadotrope cell | -- |
| E_03189 | chr6:51026850-51028001 | Forebrain | embryonic cell | -- |
Expression of Target Genes for the Enhancer