About Enhancer
| Enhancer ID: | E_02039 |
| Species: | Homo sapiens |
| Position : | chrX:49264210-49265210   |
| Year: | 2026 |
| Title: | FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 41237776 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary regulatory T cells |
| Cell Type: | regulatory T cell |
| Cell Ontology ID: | CL:0000815 |
| Experiment Type: | Promoter functional perturbation assay; TF binding assay |
| High Throughput Method: | Pooled CRISPRi locus-tiling screen; H3K27ac ChIP-seq; HIC1 ChIP-seq |
| Low Throughput Method: | Paired-Cas9 RNP tiled deletion; FOXP3 flow cytometry |
About Target Gene
| Target gene : | FOXP3 |
About TF
| TF name : | HIC1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HIC1 | Direct p53 effectors | pid | 141 |
| HIC1 | E2F transcription factor network | pid | 77 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02124 | chrX:49264210-49265210 | NA | NA | NA |
Expression of Target Genes for the Enhancer