About Enhancer
| Enhancer ID: | E_02043 |
| Species: | Mus musculus |
| Position : | chr7:45416017-45418912   |
| Year: | 2024 |
| Title: | An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 39158745 |
| MONDO: | |
| Tissue: | Embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Embryonic Stem Cells (mESCs) |
| CVCL ID: | |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, UMI-4C-seq, RNA-seq |
| Low Throughput Method: | CRISPRi, CRISPRa, ChIP-RT-qPCR, RT-RT-qPCR, 3C, Fluorescence binding assay, Circular dichroism |
About Target Gene
| Target gene : | Lhb |
About TF
| TF name : | Hmgb2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Hmgb2 | Activation of DNA fragmentation factor | reactome | 13 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer