About Enhancer
| Enhancer ID: | E_02046 |
| Species: | Mus musculus |
| Position : | chr16:10433585-10433748   |
| Year: | 2018 |
| Title: | Macrophage-specific MHC II expression is regulated by a remote Ciita enhancer controlled by NFAT5 |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 30327417 |
| MONDO: | |
| Tissue: | Spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Bone Marrow-Derived Macrophages |
| CVCL ID: | |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq |
| Low Throughput Method: | CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | Ciita |
About TF
| TF name : | Nfat5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nfat5 | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| Nfat5 | Wnt signaling pathway | kegg | 135 |
| Nfat5 | Axon guidance | kegg | 126 |
| Nfat5 | VEGF signaling pathway | kegg | 70 |
| Nfat5 | Natural killer cell mediated cytotoxicity | kegg | 125 |
| Nfat5 | T cell receptor signaling pathway | kegg | 105 |
| Nfat5 | B cell receptor signaling pathway | kegg | 70 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer